Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression
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چکیده
منابع مشابه
Interferon Resistance of Hepatitis C Virus Genotypes 1a/1b: Relationship to Structural E2 Gene Quasispecies Mutations
Hepatitis C virus (HCV) envelope glycoprotein-2 (E2) inhibits the interferon (IFN)–induced, double –stranded RNA activated protein kinase (PKR) via PKR eukaryotic initiation factor-2α phosphorylation homology domain (PePHD). Present study examined the genetic variability of the PePHD in patients receiving interferon therapy. The PePHD region from HCV genotype 1a/1b infected patients receiving I...
متن کاملSTAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α
Interferon-α (IFN-α) and IFN-λ are structurally distinct cytokines that bind to different receptors, but induce expression of similar sets of genes through Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathways. The difference between IFN-α and IFN-λ signaling remains poorly understood. Here, using the CRISPR/Cas9 system, we examine the role of STAT1 and STAT2 in ...
متن کاملResistin reinforces interferon λ-3 to eliminate hepatitis C virus with fine-tuning from RETN single-nucleotide polymorphisms
The effect of resistin (RETN) on the response to anti-HCV therapy remains unclear. A prospective cohort study was performed using 655 consecutive HCV patients, of whom 513 had completed a course of interferon-based therapy. Multivariate and GEE analyses revealed four RETN single-nucleotide polymorphisms (SNPs), rs34861192, rs3219175, rs3745367 and rs1423096, to be synergistically associated wit...
متن کاملIFN-λ: A New Class of Interferon with Distinct Functions-Implications for Hepatitis C Virus Research
Pegylated interferon-α and ribavirin (PEG-IFN/RBV) is widely used to treat chronic hepatitis C virus infection with notorious adverse reactions since the broad expression of IFN-α receptors on all nucleated cells. Accordingly, a Type III IFN with restricted receptors distribution is much safer as an alternative for HCV therapy. In addition, single nucleotide polymorphisms (SNPs) near the human ...
متن کاملthe correlation between interferon lambda 3 gene polymorphisms and susceptibility to hepatitis b virus infection
conclusions our study showed no correlation between rs12979860 and rs8099917 snps and chronic hbv infection. further studies, with larger sample sizes and different ethnicities, are necessary to validate our findings. objectives this study was carried-out to investigate the association of ifnl3 gene polymorphisms (rs12979860 and rs8099917) with hbv susceptibility, in chronic hbv-infected patien...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2016
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2015.11.027